| dc.contributor.author | Білоус, Володимир Володимирович | |
| dc.date.accessioned | 2022-11-12T12:06:10Z | |
| dc.date.available | 2022-11-12T12:06:10Z | |
| dc.date.issued | 2022 | |
| dc.identifier.citation | Білоус, В. (2022). Activity of the inflammatory process in the respiratory tract in children with bronchial asthma. Стаття. Факультет фізичної культури та здоров'я людини, Чернівецький національний університет імені Юрія Федьковича. | uk_UA |
| dc.identifier.issn | 1512-2778 | |
| dc.identifier.uri | https://archer.chnu.edu.ua/xmlui/handle/123456789/5262 | |
| dc.description.abstract | Aim of the study: To analyze the activity of the inflammatory process in the airways in children
with bronchial asthma (BA) depending on the different onset of the disease.
Materials and methods: Keeping to the principles of bioethics a comprehensive retrospective
examination of 319 children suffering from BA was performed. In 257 children (clinical group I)
bronchial asthma developed on the background of chronic obstructive bronchitis. The second
clinical group included 43 children, in whom asthma debuted after community-acquired
pneumonia. The third (III) clinical group consisted of 19 children in whom asthma was first
verified after inpatient treatment for asthmatic status.
Results: According to the severity of bronchial asthma, it was found that the representatives of the
III clinical group, compared with other patients, significantly more often had a severe course of
the disease. For patients of the I clinical group in the debut is characterized by increased
eosinophils and decreased neutrophil counts in sputum, for patients of group II - increased
eosinophils and epitheliocytes, but a decrease in lymphocytes, and for children of clinical group
III - low eosinophils sputum with a simultaneous increase in neutrophils. In particular, a
statistically significant increase in the content of VEGF, a decrease in the content of cationic
proteins, MMP-9, and interleukins-6, and -13 in the sputum indicates the predominance of
neoangiogenesis in children of clinical group III. Instead, in the representatives of the II clinical
group the remodeling processes were mainly caused by the inflammatory process with the release
of intracellular eosinophilic cationic proteins.
Conclusion: These data indicate the discrete nature of the type and severity of the inflammatory
process of the respiratory tract in the dynamics of observation in children of clinical comparison
groups, which suggests the presence of certain phenotypic differences due to the alternative onset
of the disease, which in turn was determined by different triggers. Such deviations of the
inflammatory process indicate that patients with asthma require a personalized approach to
differentiated diagnostic monitoring and targeted anti-inflammatory treatment, taking into account
the peculiarities of the onset of the disease. | uk_UA |
| dc.description.sponsorship | Фізичної реабілітації, ерготерапії та домедичної допомоги. | uk_UA |
| dc.language.iso | en | uk_UA |
| dc.publisher | Georgian Respiratory Journal | uk_UA |
| dc.subject | children | uk_UA |
| dc.subject | sputum markers | uk_UA |
| dc.subject | bronchial asthma | uk_UA |
| dc.title | Activity of the inflammatory process in the respiratory tract in children with bronchial asthma | uk_UA |
| dc.type | Article | uk_UA |
