In this paper, the network readiness of the enterprises in Ukraine has been analyzed. National statistics data and international indices were used to measure and characterize fundamental changes in Ukraine at the economic and business levels. These changes are influenced by modern information technologies and new global information society tendencies. Indicators used to measure the network readiness of the enterprises were examined. Obtained results show positive dynamic improvement and simplification of enterprise activities under network economy growth in Ukraine. The detailed examination of individual indicators confirmed infrastructure and availability of digital content and prevalence of the business and innovation environment over the network economy's actual enterprise performance in 2018. An integral indicator was used to measure the level of actual use of information and communication technologies, the implementation of innovations, automated data exchange by national enterprises, and network readiness. The integral indicator of the enterprises' network readiness is a comprehensive summary of 46 components were grouped by authors into the following blocks: infrastructure and availability of digital content; business and innovation environment; business exploitation. The analysis of the selected block of indicators for 2010-2018 showed positive network readiness dynamics. The gap between the enterprises' network readiness at the regional and national levels was measured by calculating the distance between the network vector of a particular region and the average values in Ukraine. In 2018, the length of the network vector Aj was 57.27. Of the 622 enterprises surveyed, almost 94% used computers. Among the studied enterprises, a large proportion used the Internet to carry out banking operations and automated data exchange, receive tax forms, send or forward completed forms. A negative trend towards an increase in the gap between information and communication technologies at the regional and national levels has been revealed. The studied indices of the enterprises' network readiness in Ukraine enabled us to measure the level of digital infrastructure, business climate, business opportunities provided to some extent by information and communication technologies and the Internet, facilitating business operations and their quantity. The authors selected indices related to network readiness, analyzed the components which influence businesses and region capability to exploit information communication technologies to develop.